Recent Grants

The U.S. Army Medical Research and Development Command's (USAMRDC) mission is to provide solutions to medical problems of importance to the American Service member at home and abroad, as well as to the general public at large. The scope of this effort and the priorities attached to specific projects are influenced by changes in military and civilian medical science and technology, operational requirements, military threat assessments, and national defense strategies. Extramural research and development programs play a vital role in the fulfillment of the objectives established by the USAMRDC.

This BAA is intended to solicit extramural research and development ideas using the authority provided by United States Code, Title 10, Section 2358 (10 USC 2358).  In accordance with FAR 35.016, projects funded under this BAA must be for basic and applied research to support scientific study and experimentation directed toward advancing the state of the art or increasing knowledge or understanding rather than focusing on development of a specific system or hardware solution. Research and development funded through this BAA are intended and expected to benefit and inform both military and civilian medical practice and knowledge. This BAA utilizes competitive procedures in accordance with 10 USC 2302(2)(B) for the selection for award of science and technology (S&T) proposals. For purposes of this BAA, S&T includes activities involving basic research, applied research, advanced technology development, and, under certain conditions, may include activities involving advanced component development and prototypes.

Program Descriptions

Military Infectious Diseases Research Program: The Military Infectious Diseases Research Program (MIDRP) focuses on vaccines, drugs, vector detection assays, and novel prevention strategies and therapeutics to treat microbial infections, including multidrug-resistant organisms in combat wound infections, as well as vector control measures for insect vectors that transmit naturally occurring endemic diseases with demonstrated or potential capability to decrease military operational effectiveness. Malaria, bacterial diarrhea, and dengue and lethal viruses are the main areas of interest for the MIDRP. The MIDRP also has programs in multidrug-resistant bacteria and fungi, Rickettsial diseases, emerging infectious diseases (e.g., chikungunya virus, Zika virus) not found on the Defense Threat Reduction Agency (DTRA) biothreat list. The MIDRP does not support proposals/applications for funding research on any select agent biologicals or chemical warfare threats or cancer.

Research efforts that focus on novel technologies and/or Investigational New Drug (IND)-enabling preclinical and clinical studies to facilitate the development of preventive and treatment therapies for the above-mentioned research areas are of interest to the MIDRP.

The MIDRP is also interested in proposals/applications incorporating a systems biology approach. Systems biology is the study of systems of biological components, which may be molecules, cells, organisms, or entire species.

Combat Casualty Care Research Program: The Combat Casualty Care Research Program (CCCRP) provides integrated capabilities for current and future operations to reduce the mortality and morbidity associated with major combat-related trauma across the spectrum of combat casualty care including point-of-injury and pre- or out-of-hospital care, the spectrum of en route care, and facilities-based treatment. A primary emphasis of the CCCRP is to identify and develop medical techniques, knowledge products, and materiel[1] (medical devices, drugs, and biologics) for early intervention in life-threatening battle injuries and prolonged field care[2] (PFC). Because battlefield conditions impose severe constraints on available manpower, equipment, and medical supplies available for casualty care, the CCCRP places a premium on medical interventions that can be used within the battle area or as close to it as possible, before or during medical evacuation. Preferred medical techniques and materiel that can be used by combat medics must be easily transportable (i.e., small, lightweight, and durable in extreme environments and handling); devices must be easy to use and require low maintenance, with self-contained power sources as necessary. The CCCRP is interested in existing materiel for which concept and/or patient care efficacy have already been demonstrated, but that require improvement to meet military requirements.  The CCCRP is also interested in proposals/applications incorporating a systems biology approach.

Military Operational Medicine Research Program: The mission of the Military Operational Medicine Research Program (MOMRP) is to protect, optimize, and enhance the readiness and performance of Service members and their families by developing effective biomedical countermeasures against operational stressors; and to prevent and mitigate physical and psychological injuries and threats during training and operations. The MOMRP supports Army Biomedical Performance Enhancement (BPE), Human Dimension, Multi-Domain Operations (MDO), Soldier Lethality, Dense Urban Environment/Subterranean Operations, Army Big 6 Modernization Priorities, and the DoD Total Force Fitness (TFF) concepts. 

The MOMRP supports research focused on addressing and delivering actionable solutions across the military lifecycle for critical biomedical problems facing the military today and in the future. Service- and platform-specific issues are addressed through close coordination with all Services to prevent unnecessary duplication of effort. 

The highest priorities of the MOMRP are the support of the Army's six modernization priorities:

• Soldier Lethality 
• Future Vertical Lift Platforms
• Next-Generation Combat Vehicle 
• Army Network
• Long-Range Precision Fires; and 
• Air and Missile Defense

The MOMRP is divided into four Research Areas of Interest: (1) Environmental Health and Protection, (2) Injury Prevention and Reduction, (3) Physiological Health and Performance, and (4) Psychological Health and Resilience.

Clinical and Rehabilitative Medicine Research Program: The Clinical and Rehabilitative Medicine Research Program (CRMRP) focuses on the innovations required to reset our wounded Service members, both in terms of duty performance and quality of life. Innovations developed from CRMRP-supported research efforts are expected to improve restorative treatments and rehabilitative care to maximize function for return to duty (RTD) or civilian life. Medical technologies (drugs, biologics, and devices) and treatment/rehabilitation strategies (methods, guidelines, standards, and information) that will significantly improve the medical care that our wounded Service members receive within the DoD healthcare system are of particular interest. Implementation of these technologies and strategies should improve the rate of RTD of Service members, the time to RTD, clinical outcome measures, and quality of life, as well as reduce the hospital stay lengths, clinical workload (patient encounters, treatments, etc.) of caregivers, and initial and long-term costs associated with restorative and rehabilitative or acute care.

Medical Biological Defense Research Program: The DTRA Joint Science and Technology Office for Chemical and Biological Defense (JSTO-CBD) manages research directed toward medical biological defense. The DTRA JSTO-CBD has limited funding for proposals/applications submitted through the USAMRDC BAA. DTRA also seeks proposals/applications for its requirements through the Federal Business Opportunities (FedBizOpps) and the DoD Small Business Innovation Research (SBIR) Program solicitations. 

Medical Chemical Defense Research Program: The Medical Chemical Defense Research Program (MCDRP) seeks to preserve combat effectiveness through timely provision of medical countermeasures in response to Joint Service Chemical Warfare Defense Requirements. The fundamental orientation of the program is to protect U.S. Forces from the effects of chemical warfare agents by developing protective, pretreatment, and prophylactic products, providing products usable by the individual Service member for immediate treatment of chemical warfare agent exposures, developing antidotes/therapeutics to chemical warfare agents, defining care procedures for chemical warfare agent casualties, and advancing management of these casualties. The medical countermeasures are intended to preserve and sustain the Service members' combat effectiveness in the face of combined threats from chemical and conventional munitions on the integrated battlefield. The MCDRP is interested in applications and products incorporating a systems biology approach.

Medical Simulation and Information Sciences Research Program: The mission of the Medical Simulation and Information Sciences Research Program (MSISRP) is to execute medical science and technology (S&T) programs to strategically bridge gaps in capabilities required to support and enable the Warfighter responsively and responsibly creating and developing emerging and disruptive military medical capabilities with a focus on full lifecycle impact and integration of its research activities.

Radiation Health Effects Research Program: The Radiation Health Effects Research Program (RHERP) focuses on developing medical countermeasures for acute ionizing radiation injury. The program has interest in the following research focus areas: post-exposure mitigation of radiation injury; protection and prevention of injury from ionizing radiation exposure (prophylaxis); mechanism of radiation injury; and development of novel biodosimetry tools.